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-synuclein, which can be a main ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, and that is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) stress, counsel that dysfunction on the intracellular proteinase systems, for instance ubiquitin-proteasome process or lysosomal system, which eliminates needless tox
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